Soft-tissue sarcomas (STS) are a group of rare, heterogeneous, and aggressive tumors, with high metastatic risk and relatively few efficient systemic therapies.In the quest for new treatments, the immune system represents an attractive therapeutic target.Recently, PD1/PDL1 inhibitors showed very promising results in patients with solid tumors.PDL1

The article addresses the problem of distortions of the spiritual experience, with which psychotherapist encounters while working with religious clients.In the focus are the phenomena of substitution, which are understood as distortions of the spiritual experience.The person himself sees them as normal, spiritually right, healthy and as being signs

The successful establishment of a species in a given habitat depends on the ability of each belle de grasse of its developing stages to adapt to the environment.In order to understand this process we have studied the adaptation of a euryhaline fish, the sea-bass Dicentrarchus labrax, to various salinities during its ontogeny.The expression and loca

A phrase heard often in recent years, advanced composite materials like Al/SiC metal matrix composite is gradually becoming very important materials in auto and aerospace industries due to their superior properties.The present study examines the mechanical properties of aluminum (Al-6063)/SiC Silicon carbide reinforced particles metal-matrix compos

The growing number of renewable energy replacing conventional generators results in a loss of the reserve for frequency control in power systems, while many industrial power grids often have excess energy supply due to abundant wind and solar energy resources.This paper proposes a secondary frequency control (SFC) strategy that allows industrial zu